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Mental Health and Substance Use Challenges (Volume 103)
Quarterly Article
Rachel Donnelly
Mateo P. Farina
Jul 30, 2026
May 6, 2026
June 2026
Back to The Milbank Quarterly
Policy Points:
See all articles in the special issue, Mental Health and Substance Use Challenges Facing the United States: What Can State Policymakers Do?
Mental health (e.g., anxiety, depression) continues to be a major public health concern in the United States that impacts millions of individuals, their families, and communities. Approximately 21% of adults 18 years and older, or 55 million adults, reported symptoms of recent depression in 2022, demonstrating the wide reach of mental health challenges.1 Moreover, rates of depression and anxiety spiked at the onset of the COVID-19 pandemic and have not fully recovered to prepandemic levels, indicating that mental health will continue to be a major concern for population health.1-3 In addition to the impacts on individuals and their families, mental health challenges have vast economic and social costs. For instance, estimates suggest that depression accounted for $83 billion in costs in 2000,4 and suicide and nonfatal self-harm injuries, which are linked to mental health, cost the United States over $500 billion annually from 2015 to 2020.5
However, significant variation in mental health exists across states, pointing to states as an important contextual environment to consider. In this perspective, we propose a theoretical perspective that examines how state-level variation in mental health is shaped by clusters of state policies, especially economic and social support policies. To this end, we first describe patterns of population mental health at the national and state level. We then argue that differences in state policy contexts contribute to different rates of mental health outcomes (e.g., depression, anxiety) across states. We conclude by recommending key areas for future research on state policy contexts and mental health that can yield greater insight into potential policy solutions to improve mental health.
Terlizzi EP, Zablotsky B. Symptoms of anxiety and depression among adults: United States, 2019 and 2022. Natl Health Stat Report. 2024; 213:CS353885.
Czeisler MÉ, Howard ME, Rajaratnam SMW. Mental health during the COVID-19 pandemic: challenges, populations at risk, implications, and opportunities. Am J Health Promot. 2021; 35(2): 301–311.
Ettman CK., Abdalla SM, Cohen GH, Sampson L, Vivier PM, Galea S. Prevalence of depression symptoms in US adults before and during the COVID-19 pandemic. JAMA Netw Open. 2020; 3(9):e2019686.
Gelenberg AJ. The prevalence and impact of depression. J Clin Psychiatry. 2010; 71(3):e06.
Peterson C, Haileyesus T, Stone DM. Economic cost of U.S. suicide and nonfatal self-harm. Am J Prev Med. 2024; 67(1): 129–133.